ProTEoME – PROteomic Tools to assess Endocrine disruptiOn MEchanisms

Abstract/Aim
This project aims to study the mechanisms underlying the toxicity of endocrine disrupting compounds (EDCs), molecules that interfere with the synthesis, secretion, transport, action or elimination of hormones of an organism, affecting its homeostasis, reproduction, development, behavior, immunity, and neurology. Through an ecotoxicological approach and modern molecular methodologies, such as proteome analysis, the international and multidisciplinary team aims to elucidate the complexity of the molecular interactions that culminate in these individual and population effects, focusing on aquatic organisms (midge larvae) in order to assess the impact EDCs can cause in individuals, populations and ecosystems, contributing for an effective environmental risk assessment.

Keywords
Biomarkers; Proteomics; Ecotoxicology; Endocrine disruption

Partners
Institute of Environmental Diagnosis and Water Studies (IDAEA / CSIC); LABERCA – Laboratoire d’Étude des Résidus et Contaminants dans les Aliments; University of Gent – Faculty of Bioscience Engineering (Belgium); Center for Environmental and Marine Studies – CESAM, University of Aveiro – UA

Coordinator MARE, Polytechnic of Leiria: Marco Lemos – marco.lemos@ipleiria.pt

Funding
164.102,00€ (IPLeiria) | POCI – Programa Operacional Competitividade e Internacionalização/FCT – Fundação para a Ciência e a Tecnologia // Duration 2016-2019